![]() ![]() Neural differences in regions important for social cognitive processing, such as the precuneus, temporoparietal junctions, medial prefrontal cortex, and inferior frontal gyri, have also been reported in this disease ( McAdams and Krawczyk, 2011, 2014 Schulte-Ruther et al., 2012 McAdams et al., 2015, 2016), but it remains unclear how genetic differences might impact social brain function in AN. Differences in social behaviors are observed in AN, such as impaired recognition of the emotional content in faces, and reduced mentalization ( Oldershaw et al., 2011 Tchanturia et al., 2011 Lang et al., 2016). This pilot study suggests that in anorexia nervosa, differences related to OXTR SNP rs2254298 may alter neural responses to social stimuli and disrupt the engagement and disengagement of the default mode network.Īnorexia nervosa (AN) is an illness that includes altered perceptions related to body-image and self-esteem in concert with an inability to maintain a healthy body weight. Development of a mechanistic, biological model of how social behavior is impacted by mental illness requires linking genes to functional brain activations in disease. ![]() ![]() Differences in the other OXTR SNP, rs53576, did not result in detectable neural differences in either whole brain or region of interest analyses. Carriers of the A allele for OXTR rs2254298 (2 AA and 10 AG) showed significantly reduced activation of portions of the posterior cingulate cortex and medial prefrontal cortex for social stimuli as well as greater negative connectivity between the posterior cingulate and the occipital lobe relative to the GG subjects for rs2254298. Oxytocin receptor single nucleotide polymorphisms rs2254298 or rs53576 and neural responses to social stimuli were evaluated in adult women with or recovered from anorexia nervosa using functional magnetic resonance imaging. Oxytocin is a neurotransmitter related to both feeding and social behavior anorexia nervosa is a psychiatric illness defined by reduced food intake, weight loss, and problems in social perceptions. 3Department of Psychiatry, University of Texas at Southwestern Medical School, Dallas, TX, United States.2Center for Brain Health, University of Texas at Dallas, Dallas, TX, United States.1Department of Psychology, Southern Methodist University, Dallas, TX, United States.Margarita Sala 1, Kihwan Han 2, Summer Acevedo 3, Daniel C. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. Archives
August 2023
Categories |